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Selected publications

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  1. László L, Sarkadi B, Hegedűs T. Jump into a New Fold-A Homology Based Model for the ABCG2/BCRP Multidrug Transporter. PLoS One. 2016 Oct 14;11(10):e0164426 (2016) PubMed: 27741279
  2. Szollosi D, Erdei A, Gyimesi G, Magyar C, Hegedus T. Access Path to the Ligand Binding Pocket May Play a Role in Xenobiotics Selection by AhR. PLOS ONE 11:(1) p. e0146066. (2016) PubMed: 26727491
  3. Hegedűs T, Chaubey PM, Várady G, Szabó E, Sarankó H, Hofstetter L, Roschitzki B, Stieger B, Sarkadi B. Inconsistencies in the red blood cell membrane proteome analysis: generation of a database for research and diagnostic applications. Database (Oxford). 2015 Jun 14;2015:bav056 PubMed: 26078478
  4. Tóth A, Brózik A, Szakács G, Sarkadi B, Hegedüs T. A novel mathematical model describing adaptive cellular drug metabolism and toxicity in the chemoimmune system. PLoS One. 2015 Feb 20;10(2):e0115533 PubMed: 25699998
  5. Veit, G., Avramescu, R.G., Perdomo, D., Phuan, P.W., Bagdany, M., Apaja, P.M., Borot, F., Szöllősi, D., Wu, Y.S., Finkbeiner, W.E., Hegedus, T., Verkman, A.S., Lukacs, G.L., Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression. Sci Transl Med. 2014 Jul 23;6(246):246 PubMed: 25101887
  6. Szöllősi, D., Horváth, T., Han, KH, Dokholyan, N.V., Tompa, P., Kalmár, L., Hegedűs, T., Discrete molecular dynamics can predict helical prestructured motifs in disordered proteins. PLOS ONE 2014 (accepted for publication)
  7. Sarankó, H., Tordai, H., Telbisz, Á., Özvegy-Laczka, C., Erdős, G., Sarkadi, B., Hegedűs, T., Effects of the gout-causing Q141K polymorphism and a CFTR ΔF508 mimicking mutation on the processing and stability of the ABCG2 protein. Biochem Biophys Res Commun. 2013, 19:140-5. PubMed: 23800412
  8. Okiyoneda, T., Veit, G., Dekkers, J.F., Bagdany, M., Soya, N., Xu, H., Roldan, A., Verkman, A.S., Kurth, M., Simon, A., Hegedus, T., Beekman, J.M., Lukacs, G.L., Mechanism-based corrector combination restores ΔF508-CFTR folding and function. Nature Chemical Biology 2013, 9:444-54. DOI:10.1038/NChemBio.1253
  9. Hegedűs, T., Gyimesi, G., Gáspár, M.E., Szalay, K.Z., Gangal, R., Csermely, P., Potential application of network descriptions for understanding conformational changes and protonation states of ABC transporters. Curr Pharm Des. 2013, 19:4155-72. PubMed: 23170883
  10. Gyimesi, G., Borsodi, D., Sarankó, H., Tordai, H., Sarkadi, B., Hegedűs, T., ABCMdb: a database for comparative analysis of mutations in ABC transporters, and potential framework for a general application, Human Mutation 2012, 33(11):1547-56. PubMed:22693078
  11. Gyimesi, G., Ramachandran, S., Kota, P., Dokholyan, N.V., Sarkadi, B., Hegedűs, T., ATP hydrolysis at one of the two sites in ABC transporters initiates transport related conformational transitions. BBA Biomembranes 2011, 1808(12):2954-64. PubMed: 21840296;