About Our Research

At HegeLab, we are dedicated to investigating the physiological and pathological roles of transmembrane proteins using both experimental and computational methods. Our research primarily focuses on:

• Multidrug Transporters: These proteins play a critical role in protecting our body from toxic molecules, as well as enabling cancer cells to evade anticancer drugs.
• CFTR Chloride Channel: Mutations in this channel are responsible for cystic fibrosis, the most frequent and lethal genetic disease among the white population.
• Calcium Pumps (SERCA and PMCA): These pumps are key players in cellular signaling, with significant implications for cell migration and cancer metastasis.
• SARS-CoV-2 Envelope Protein: We study how this viral protein interacts with and modulates the function of SERCA, offering insights into viral mechanisms and potential therapeutic targets.

Our Commitment to the Scientific Community

Beyond our research endeavors, HegeLab is committed to providing valuable data, tools, and standards to the scientific community. Some of our key contributions include:

• AlphaMissense Data: Offering easy access to crucial missense mutation data.
• 3D Beacons: Collaborating within the Elixir framework, alongside EBI and numerous other laboratories, to advance the understanding of protein structures.