Publications - HegeLab

2024

  1. J Med Chem. 2024 Aug 22;67(16):13891-13908. [DOI: 10.1021/acs.jmedchem.4c00685] [PMID: 39137389]
    Synthesis and Biological Evaluation of Pyrazole-Pyrimidones as a New Class of Correctors of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR).
    Vaccarin C, Veit G, Hegedus T, Torres O, Chilin A, Lukacs GL, Marzaro G
  2. Autophagy. 2024 Jul;20(7):1639-1650. [DOI: 10.1080/15548627.2024.2322493] [PMID: 38411137]
    PtdIns4P is required for the autophagosomal recruitment of STX17 (syntaxin 17) to promote lysosomal fusion.
    Laczko-Dobos H, Bhattacharjee A, Maddali AK, Kincses A, Abuammar H, Sebok-Nagy K, Pali T, Der A, Hegedus T, Csordas G, Juhasz G
  3. J Physiol. 2024 Apr;602(8):1551-1564. [DOI: 10.1113/JP284179] [PMID: 36876504]
    Plasma membrane Ca(2+) pump isoform 4 function in cell migration and cancer metastasis.
    Naffa R, Hegedus L, Hegedus T, Toth S, Papp B, Tordai A, Enyedi A
  4. Sci Data. 2024 May 14;11(1):495. [DOI: 10.1038/s41597-024-03327-8] [PMID: 38744964]
    Analysis of AlphaMissense data in different protein groups and structural context.
    Tordai H, Torres O, Csepi M, Padanyi R, Lukacs GL, Hegedus T

2023

  1. Membranes (Basel). 2023 Oct 4;13(10):822. [DOI: 10.3390/membranes13100822] [PMID: 37887994]
    Expression, Function and Trafficking of the Human ABCG2 Multidrug Transporter Containing Mutations in an Unstructured Cytoplasmic Loop.
    Mozner O, Zambo B, Bartos Z, Gergely A, Szabo KS, Jezso B, Telbisz A, Varady G, Homolya L, Hegedus T, Sarkadi B
  2. Nat Commun. 2023 Oct 27;14(1):6868. [DOI: 10.1038/s41467-023-42586-8] [PMID: 37891162]
    Folding correctors can restore CFTR posttranslational folding landscape by allosteric domain-domain coupling.
    Soya N, Xu H, Roldan A, Yang Z, Ye H, Jiang F, Premchandar A, Veit G, Cole SPC, Kappes J, Hegedus T, Lukacs GL
  3. J Mol Biol. 2023 Nov 1;435(21):168272. [DOI: 10.1016/j.jmb.2023.168272] [PMID: 37709009]
    CoMemMoRFPred: Sequence-based Prediction of MemMoRFs by Combining Predictors of Intrinsic Disorder, MoRFs and Disordered Lipid-binding Regions.
    Basu S, Hegedus T, Kurgan L
  4. Int J Mol Sci. 2023 Jul 12;24(14):11341. [DOI: 10.3390/ijms241411341] [PMID: 37511101]
    Synergistic Inhibitory Effect of Quercetin and Cyanidin-3O-Sophoroside on ABCB1.
    Singh K, Patil RB, Patel V, Remenyik J, Hegedus T, Goda K

2022

  1. Comput Struct Biotechnol J. 2022 May 23;20:2587-2599. [DOI: 10.1016/j.csbj.2022.05.036] [PMID: 35685375]
    Nanomechanics combined with HDX reveals allosteric drug binding sites of CFTR NBD1.
    Padanyi R, Farkas B, Tordai H, Kiss B, Grubmuller H, Soya N, Lukacs GL, Kellermayer M, Hegedus T
  2. Gigascience. 2022 Nov 30;11:giac118. [DOI: 10.1093/gigascience/giac118] [PMID: 36448847]
    3D-Beacons: decreasing the gap between protein sequences and structures through a federated network of protein structure data resources.
    Varadi M, Nair S, Sillitoe I, Tauriello G, Anyango S, Bienert S, Borges C, Deshpande M, Green T, Hassabis D, Hatos A, Hegedus T, Hekkelman ML, Joosten R, Jumper J, Laydon A, Molodenskiy D, Piovesan D, Salladini E, Salzberg SL, Sommer MJ, Steinegger M, Suhajda E, Svergun D, Tenorio-Ku L, Tosatto S, Tunyasuvunakool K, Waterhouse AM, Zidek A, Schwede T, Orengo C, Velankar S
  3. Cell Mol Life Sci. 2022 Jan 15;79(1):73. [DOI: 10.1007/s00018-021-04112-1] [PMID: 35034173]
    Ins and outs of AlphaFold2 transmembrane protein structure predictions.
    Hegedus T, Geisler M, Lukacs GL, Farkas B
  4. Int J Mol Sci. 2022 Nov 8;23(22):13744. [DOI: 10.3390/ijms232213744] [PMID: 36430223]
    The Reentry Helix Is Potentially Involved in Cholesterol Sensing of the ABCG1 Transporter Protein.
    Hegyi Z, Hegedus T, Homolya L
  5. Int J Mol Sci. 2022 Aug 9;23(16):8877. [DOI: 10.3390/ijms23168877] [PMID: 36012140]
    Comprehensive Collection and Prediction of ABC Transmembrane Protein Structures in the AI Era of Structural Biology.
    Tordai H, Suhajda E, Sillitoe I, Nair S, Varadi M, Hegedus T

2021

  1. Br J Pharmacol. 2021 Mar;178(5):1200-1217. [DOI: 10.1111/bph.15365] [PMID: 33450052]
    The mechanism of non-blocking inhibition of sodium channels revealed by conformation-selective photolabeling.
    Foldi MC, Pesti K, Zboray K, Toth AV, Hegedus T, Malnasi-Csizmadia A, Lukacs P, Mike A
  2. Nucleic Acids Res. 2021 Jan 8;49(D1):D355-D360. [DOI: 10.1093/nar/gkaa954] [PMID: 33119751]
    The MemMoRF database for recognizing disordered protein regions interacting with cellular membranes.
    Csizmadia G, Erdos G, Tordai H, Padanyi R, Tosatto S, Dosztanyi Z, Hegedus T
  3. Cell Mol Life Sci. 2021 Mar;78(5):2329-2339. [DOI: 10.1007/s00018-020-03651-3] [PMID: 32979053]
    The transport pathway in the ABCG2 protein and its regulation revealed by molecular dynamics simulations.
    Nagy T, Toth A, Telbisz A, Sarkadi B, Tordai H, Tordai A, Hegedus T

2020

  1. FEBS Lett. 2020 Dec;594(23):4012-4034. [DOI: 10.1002/1873-3468.13947] [PMID: 33015850]
    The ABCG2/BCRP transporter and its variants - from structure to pathology.
    Sarkadi B, Homolya L, Hegedus T
  2. Methods Mol Biol. 2020;2112:123-130. [DOI: 10.1007/978-1-0716-0270-6_9] [PMID: 32006282]
    Using MemBlob to Analyze Transmembrane Regions Based on Cryo-EM Maps.
    Csizmadia G, Farkas B, Katona E, Tusnady GE, Hegedus T
  3. Bioinformatics. 2020 Apr 15;36(8):2595-2598. [DOI: 10.1093/bioinformatics/btz539] [PMID: 31290936]
    MemBlob database and server for identifying transmembrane regions using cryo-EM maps.
    Farkas B, Csizmadia G, Katona E, Tusnady GE, Hegedus T
  4. FEBS Lett. 2020 Dec;594(23):3986-4000. [DOI: 10.1002/1873-3468.13983] [PMID: 33125703]
    A twist in the ABC: regulation of ABC transporter trafficking and transport by FK506-binding proteins.
    Geisler M, Hegedus T
  5. Cell Mol Life Sci. 2020 Feb;77(4):765-778. [DOI: 10.1007/s00018-019-03211-4] [PMID: 31327045]
    Discovering the chloride pathway in the CFTR channel.
    Farkas B, Tordai H, Padanyi R, Tordai A, Gera J, Paragi G, Hegedus T

2019

  1. Cells. 2019 Oct 8;8(10):1215. [DOI: 10.3390/cells8101215] [PMID: 31597297]
    Cellular Processing of the ABCG2 Transporter-Potential Effects on Gout and Drug Metabolism.
    Mozner O, Bartos Z, Zambo B, Homolya L, Hegedus T, Sarkadi B

2018

  1. Sci Rep. 2018 May 10;8(1):7487. [DOI: 10.1038/s41598-018-25695-z] [PMID: 29749379]
    Clinically relevant mutations in the ABCG2 transporter uncovered by genetic analysis linked to erythrocyte membrane protein expression.
    Zambo B, Bartos Z, Mozner O, Szabo E, Varady G, Poor G, Palinkas M, Andrikovics H, Hegedus T, Homolya L, Sarkadi B
  2. Comput Struct Biotechnol J. 2018 Oct 18;16:396-403. [DOI: 10.1016/j.csbj.2018.10.008] [PMID: 30425800]
    Quantitative comparison of ABC membrane protein type I exporter structures in a standardized way.
    Csizmadia G, Farkas B, Spagina Z, Tordai H, Hegedus T

2017

  1. Sci Rep. 2017 Sep 5;7(1):10462. [DOI: 10.1038/s41598-017-09058-8] [PMID: 28874747]
    Transcriptome analysis of inflammation-related gene expression in endothelial cells activated by complement MASP-1.
    Schwaner E, Nemeth Z, Jani PK, Kajdacsi E, Debreczeni ML, Doleschall Z, Dobo J, Gal P, Rigo J, Andras K, Hegedus T, Cervenak L
  2. Biochem Biophys Res Commun. 2017 Sep 30;491(4):986-993. [DOI: 10.1016/j.bbrc.2017.07.165] [PMID: 28774558]
    Molecular dynamics of the cryo-EM CFTR structure.
    Tordai H, Leveles I, Hegedus T
  3. Database (Oxford). 2017 Jan 1;2017(1):bax023. [DOI: 10.1093/database/bax023] [PMID: 28365738]
    ABCMdb reloaded: updates on mutations in ATP binding cassette proteins.
    Tordai H, Jakab K, Gyimesi G, Andras K, Brozik A, Sarkadi B, Hegedus T
  4. Int J Mol Sci. 2017 Aug 22;18(8):1820. [DOI: 10.3390/ijms18081820] [PMID: 28829359]
    GLUT10-Lacking in Arterial Tortuosity Syndrome-Is Localized to the Endoplasmic Reticulum of Human Fibroblasts.
    Gamberucci A, Marcolongo P, Nemeth CE, Zoppi N, Szarka A, Chiarelli N, Hegedus T, Ritelli M, Carini G, Willaert A, Callewaert BL, Coucke PJ, Benedetti A, Margittai E, Fulceri R, Banhegyi G, Colombi M

2016

  1. PLoS One. 2016 Oct 14;11(10):e0164426. [DOI: 10.1371/journal.pone.0164426] [PMID: 27741279]
    Jump into a New Fold-A Homology Based Model for the ABCG2/BCRP Multidrug Transporter.
    Laszlo L, Sarkadi B, Hegedus T
  2. Cell Mol Life Sci. 2016 May;73(9):1927-37. [DOI: 10.1007/s00018-015-2118-5] [PMID: 26708291]
    The linker region of breast cancer resistance protein ABCG2 is critical for coupling of ATP-dependent drug transport.
    Macalou S, Robey RW, Jabor Gozzi G, Shukla S, Grosjean I, Hegedus T, Ambudkar SV, Bates SE, Di Pietro A
  3. Org Biomol Chem. 2016 Jul 7;14(25):6071-8. [DOI: 10.1039/c6ob00810k] [PMID: 27244693]
    A systematic study of protein labeling by fluorogenic probes using cysteine targeting vinyl sulfone-cyclooctyne tags.
    Soveges B, Imre T, Szende T, Poti AL, Cserep GB, Hegedus T, Kele P, Nemeth K
  4. PLoS One. 2016 Jan 4;11(1):e0146066. [DOI: 10.1371/journal.pone.0146066] [PMID: 26727491]
    Access Path to the Ligand Binding Pocket May Play a Role in Xenobiotics Selection by AhR.
    Szollosi D, Erdei A, Gyimesi G, Magyar C, Hegedus T

2015

  1. Adv Cancer Res. 2015;125:97-137. [DOI: 10.1016/bs.acr.2014.10.004] [PMID: 25640268]
    Lipid regulation of the ABCB1 and ABCG2 multidrug transporters.
    Hegedus C, Telbisz A, Hegedus T, Sarkadi B, Ozvegy-Laczka C
  2. Database (Oxford). 2015 Jun 14;2015:bav056. [DOI: 10.1093/database/bav056] [PMID: 26078478]
    Inconsistencies in the red blood cell membrane proteome analysis: generation of a database for research and diagnostic applications.
    Hegedus T, Chaubey PM, Varady G, Szabo E, Saranko H, Hofstetter L, Roschitzki B, Stieger B, Sarkadi B
  3. PLoS One. 2015 Feb 20;10(2):e0115533. [DOI: 10.1371/journal.pone.0115533] [PMID: 25699998]
    A novel mathematical model describing adaptive cellular drug metabolism and toxicity in the chemoimmune system.
    Toth A, Brozik A, Szakacs G, Sarkadi B, Hegedus T

2014

  1. PLoS One. 2014 Apr 24;9(4):e95795. [DOI: 10.1371/journal.pone.0095795] [PMID: 24763499]
    Discrete molecular dynamics can predict helical prestructured motifs in disordered proteins.
    Szollosi D, Horvath T, Han KH, Dokholyan NV, Tompa P, Kalmar L, Hegedus T
  2. Sci Transl Med. 2014 Jul 23;6(246):246ra97. [DOI: 10.1126/scitranslmed.3008889] [PMID: 25101887]
    Some gating potentiators, including VX-770, diminish DeltaF508-CFTR functional expression.
    Veit G, Avramescu RG, Perdomo D, Phuan PW, Bagdany M, Apaja PM, Borot F, Szollosi D, Wu YS, Finkbeiner WE, Hegedus T, Verkman AS, Lukacs GL

2013

  1. Curr Pharm Des. 2013;19(23):4155-72. [DOI: 10.2174/1381612811319230002] [PMID: 23170883]
    Potential application of network descriptions for understanding conformational changes and protonation states of ABC transporters.
    Hegedus T, Gyimesi G, Gaspar ME, Szalay KZ, Gangal R, Csermely P
  2. Nat Chem Biol. 2013 Jul;9(7):444-54. [DOI: 10.1038/nchembio.1253] [PMID: 23666117]
    Mechanism-based corrector combination restores DeltaF508-CFTR folding and function.
    Okiyoneda T, Veit G, Dekkers JF, Bagdany M, Soya N, Xu H, Roldan A, Verkman AS, Kurth M, Simon A, Hegedus T, Beekman JM, Lukacs GL
  3. Biochem Biophys Res Commun. 2013 Jul 19;437(1):140-5. [DOI: 10.1016/j.bbrc.2013.06.054] [PMID: 23800412]
    Effects of the gout-causing Q141K polymorphism and a CFTR DeltaF508 mimicking mutation on the processing and stability of the ABCG2 protein.
    Saranko H, Tordai H, Telbisz A, Ozvegy-Laczka C, Erdos G, Sarkadi B, Hegedus T
  4. Biochem J. 2013 Mar 1;450(2):387-95. [DOI: 10.1042/BJ20121485] [PMID: 23205634]
    Effects of the lipid environment, cholesterol and bile acids on the function of the purified and reconstituted human ABCG2 protein.
    Telbisz A, Ozvegy-Laczka C, Hegedus T, Varadi A, Sarkadi B

2012

  1. Hum Mutat. 2012 Nov;33(11):1547-56. [DOI: 10.1002/humu.22138] [PMID: 22693078]
    ABCMdb: a database for the comparative analysis of protein mutations in ABC transporters, and a potential framework for a general application.
    Gyimesi G, Borsodi D, Saranko H, Tordai H, Sarkadi B, Hegedus T

2011

  1. Biochim Biophys Acta. 2011 Dec;1808(12):2954-64. [DOI: 10.1016/j.bbamem.2011.07.038] [PMID: 21840296]
    ATP hydrolysis at one of the two sites in ABC transporters initiates transport related conformational transitions.
    Gyimesi G, Ramachandran S, Kota P, Dokholyan NV, Sarkadi B, Hegedus T
  2. Expert Opin Drug Metab Toxicol. 2011 May;7(5):623-42. [DOI: 10.1517/17425255.2011.562892] [PMID: 21410427]
    Tyrosine kinase inhibitors as modulators of ATP binding cassette multidrug transporters: substrates, chemosensitizers or inducers of acquired multidrug resistance?
    Brozik A, Hegedus C, Erdei Z, Hegedus T, Ozvegy-Laczka C, Szakacs G, Sarkadi B